Half Price Books, University City, MO http://b.hpb.com/ Get on the mailing list for offers and updates on their sales and events. This is a great place to take the books you have read and sell them–so you can buy more, of course. They also have a good selection of vinyl and CDs for the music lover.
Left Bank Books, St. Louis, MO http://leftbankbooks.com/ This longtime STL favorite is unsurpassed for bringing cool authors and events to the area.
The Novel Neighbor, Webster Groves, MO http://thenovelneighbor.com/ Drive slowly as you’re looking for this small but excellent store. The best perk they offer (other than a great and friendly staff) is a lending service for Advance Reader Copies. Let your voice be heard!
Main Street Books, St. Charles, MO http://www.mainstreetbooks.net/ New owners, same fabulous store. Hint: the best books (and seats) are upstairs.
Books Galore, Festus, MO http://books-galore.com/ If you can’t find it anywhere else, you will find it here. They will also happily order new books if what you want isn’t in stock.